Uncover primary receptors and off-targets

Retrogenix’s cell microarray technology is the most powerful solution for identifying the specific human plasma membrane and secreted proteins that are targeted by antibodies, proteins, small molecules, viruses, CAR T cells and other ligands. We discover high quality, exploitable drug targets and mechanisms of action for our global pharmaceutical clients as well as screening for potential off-targets to inform lead selection and assist with safety assessment.

  • High success rates
  • High specificity
  • Low false positive rates
  • Rapid turnaround (as little as 3 weeks)

Our unrivalled technology identifies interactions both with cell surface receptors and secreted proteins by screening test ligands for binding against over 6,200 full length proteins that are individually over-expressed in human cells. This physiologically-relevant system, coupled with our broad protein coverage, allows even low affinity interactions to be detected with a high degree of sensitivity and specificity.

Retrogenix works with small biotechs and leading academic groups through to major pharmaceutical companies, currently helping nineteen of the world’s top twenty drug developers to bring new therapeutics to market faster.

The University of Sheffield
Aveo Oncology - The Human Response
Theraclone Sciences
Bluebird Bio
The Center for Infectious Disease Research
Compugen Logo
The University of Copenhagen
Lund University
NIH - National Institutes of Health
The University of Pennsylvania
Scripps Florida - The Scripps Research Institute
Peptinnovate Ltd - Unlocking Nature's Potential
Capella Bioscience Logo
Sanofi Logo
Unum Theraputics Logo
Celyad Logo
Retrogenix helped us to crack a very challenging problem, the result of which has significantly advanced our research. A collaborative approach, alongside an in-depth scientific and technical knowledge of their technology turned an unsuccessful initial screen into an extremely successful secondary screen. We have already committed to further studies.
Dr. Nicky Cooper, CSO, Peptinnovate
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