Uncover primary receptors and off-targets

Retrogenix’s cell microarray technology is the most powerful solution for identifying the specific human plasma membrane and secreted proteins that are targeted by antibodies, proteins, small molecules, viruses, CAR T cells and other ligands. We discover high quality, exploitable drug targets and mechanisms of action for our global pharmaceutical clients as well as screening for potential off-targets to inform lead selection and generate high quality IND-enabling specificity data.

  • High success rates
  • High specificity
  • Low false positive rates
  • Rapid turnaround (as little as 3 weeks)

Our unrivalled technology identifies interactions both with cell surface receptors and secreted proteins by screening test ligands for binding against over 6,200 full length proteins that are individually over-expressed in human cells. This physiologically-relevant system, coupled with our broad protein coverage, allows even low affinity interactions to be detected with a high degree of sensitivity and specificity.

Retrogenix, a Charles River company, works with small biotechs and leading academic groups through to major pharmaceutical companies; we are currently helping the world’s top twenty drug developers to bring new therapeutics to market faster.

Working with Retrogenix was a breeze. We had great communication with the Retrogenix team along the entire process of our protein screen and they always delivered. Their membrane protein library is a great tool for discovering novel cell surface interaction partners.
Dr. Joseph Smith, Center for Infectious Disease Research, Seattle, WA
Discovery of malaria receptor; Nature 2013 - Read more
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Aveo Oncology - The Human Response
Theraclone Sciences
Bluebird Bio
The Center for Infectious Disease Research
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The University of Copenhagen
Lund University
NIH - National Institutes of Health
The University of Pennsylvania
Scripps Florida - The Scripps Research Institute
Peptinnovate Ltd - Unlocking Nature's Potential
The University of Sheffield
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Unum Theraputics Logo
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Molecular Partners Logo
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