Key applications of cell microarray technology

Target deconvolution

of phenotypic molecules to identify new disease-relevant drug targets

Receptor identification

for natural protein ligands, peptides or viruses, providing critical breakthroughs in research

Identification of immune checkpoint receptors

to identify novel drug targets and mechanisms for immuno-therapy development

Off-target screening of biotherapeutics

for safety assessment and lead selection

CAR-T cell cross-reactivity screening

to confirm specificity of engineered whole T-cells

Hit validation & follow-on analysis

follow-on flow cytometry screening

Identifying precisely how a biological or chemical entity interacts with the human cell is fundamental to furthering our understanding of both normal biological and disease processes as well as revealing the mechanism of action of drugs and their potential for toxicity.

The Retrogenix technology is versatile across a range of applications identifying both primary receptors and secondary cell surface targets for a multitude of different ligands including antibodies, peptides, proteins and small molecules as well as more complex ligands like viruses, whole cells or organelles and even plasma samples from patients.

We have successfully screened a wide range of different molecules including:

Antibodies & Related Molecules
mAbs and bispecifics

Antibody fragments (e.g. ScFv, Fabs, DARPins and mimetics)

Antibody-drug conjugates (ADCs)

Fc-fusion proteins
Complex Ligands
Whole cells including CAR-T Cells


Proteins / Peptides
His-, V5- or Flag-tagged, Biotinylated

Directly fluorescently conjugated

Protein-specific secondaries, Polyclonal antisera

Purified and media supernatants

Monomers & multimers
Small Molecules
3H-labelled small molecules
The University of Sheffield
Aveo Oncology - The Human Response
Theraclone Sciences
Bluebird Bio
The Center for Infectious Disease Research
Compugen Logo
The University of Copenhagen
Lund University
NIH - National Institutes of Health
The University of Pennsylvania
Scripps Florida - The Scripps Research Institute
Peptinnovate Ltd - Unlocking Nature's Potential
We’ve developed a terrific working relationship with the team at Retrogenix and intend to utilize their microarray technology as a standard screen for future targets. Jim and Jo have become trusted collaborators and we appreciate their flexibility and willingness to work with us through some challenging issues. The quality and timeliness of the data and reports are first rate. We’ve come to rely on their results as a dependable means to confirm results from traditional crossreactivity studies and to identify additional potential unexpected interactions.
Amy Bourdeau, ‎Senior Preclinical Development Coordinator, Bluebird bio