Key applications of cell microarray technology

Target deconvolution

of phenotypic molecules to identify new disease-relevant drug targets


Receptor identification

for natural protein ligands, peptides or viruses, providing critical breakthroughs in research


Identification of immune checkpoint receptors

to identify novel drug targets and mechanisms for immuno-therapy development


Off-target screening of biotherapeutics

for safety assessment and lead selection


CAR-T cell cross-reactivity screening

to confirm specificity of engineered whole T-cells


Further hit validation

follow-on flow cytometry screening

Identifying precisely how a biological or chemical entity interacts with the human cell is fundamental to furthering our understanding of both normal biological and disease processes as well as revealing the mechanism of action of drugs and their potential for toxicity.

The Retrogenix technology is versatile across a range of applications, identifying primary receptors, secondary cell surface and secreted protein targets for a multitude of different ligands including antibodies, peptides, proteins and small molecules as well as more complex ligands like viruses, whole cells or organelles and even plasma samples from patients.

We have successfully screened a wide range of different molecules including:

Antibodies & Related Molecules
mAbs and bispecifics

Antibody fragments (e.g. ScFv, Fabs, DARPins and mimetics)

Antibody-drug conjugates (ADCs)

Fc-fusion proteins
Complex Ligands
Whole cells including CAR-T Cells

Viruses

Organelles
Proteins / Peptides
His-, V5- or Flag-tagged, Biotinylated

Directly fluorescently conjugated

Protein-specific secondaries, Polyclonal antisera

Purified and media supernatants

Monomers & multimers
Small Molecules
3H-labelled small molecules

Can’t see your molecule type? Get in touch to discuss how we can screen your ligand.

Pfizer
The University of Sheffield
Aveo Oncology - The Human Response
Theraclone Sciences
BioInvent
AstraZeneca
Bluebird Bio
glycotope_logo
The Center for Infectious Disease Research
Compugen Logo
The University of Copenhagen
Lund University
MedImmune
NIH - National Institutes of Health
The University of Pennsylvania
Scripps Florida - The Scripps Research Institute
Peptinnovate Ltd - Unlocking Nature's Potential
Capella Bioscience Logo
Sanofi Logo
Unum Theraputics Logo
Celyad Logo
Working with Retrogenix was a breeze. We had great communication with the Retrogenix team along the entire process of our protein screen and they always delivered. Their membrane protein library is a great tool for discovering novel cell surface interaction partners.
Dr. Joseph Smith, Center for Infectious Disease Research, Seattle, WA