Below is a selection of our recent papers and poster presentations. If you would like to discuss how the cell microarray technology could be applied in your research please get in touch.

Off-target screening against human plasma membrane proteins confirms target specificity, or uncovers relevant secondary receptors

Kelly A, Freeth J, Soden J


Poster presentation PepTalk 2018download pdf

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ & Rangwala SM.


Nature Medicine 2017 (doi:10.1038/nm.4392). View the abstract and full article options online.

Mining naïve rabbit antibody repertoires by phage display for monoclonal antibodies of therapeutic utility

Peng H, Nerreter T, Chang J, Qi J, Li X, Karunadharma P, Martinez G, Fallahi M, Soden J, Freeth J, Beerli RR, Grawunder U, Hudecek M & Rader C.


Journal of Molecular Biology 2017, 429(19):2954-2973. View the abstract and full article options online.

Specificity screening of antibodies and related molecules using human cell microarray technology

Kingsley E, Freeth J, Soden J


Poster presentation PEGS Boston 2017download pdf

Nonclinical safety assessment in cancer immunotherapy: Off-target profiling of whole CAR T cells using plasma membrane protein arrays

Freeth J, Soden J, Bourdeau A, Rottman J, Kasperkovitz P, Friedman K, Horvath C


Poster presentation SOT 2017download pdf

Identification of human junctional adhesion molecule-1 as a functional receptor for the Hom-1 calicivirus on humans cells

Stanislav V. Sosnovtsev, Carlos Sandoval-Jaime, Gabriel I. Parra, Christine M. Tin, Ronald W. Jones, Jo Soden, Donna Barnes, Jim Freeth, Alvin W. Smith, Kim Y. Green


mBio 2017, 8:1 – View the full, open access article

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W. Wilkinson


Oncotarget 2016, 7:68278-68291 (doi: 10.18632) – View the full open-access article online.

A powerful approach to uncover immune checkpoint receptors using human plasma membrane protein arrays (PMPA)

Freeth J, Dawson S, Barnes D, Thomas H, Kingsley E & Soden J


Poster presentation PEGS Boston 2016download pdf

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth and Ralph Minter


Molecular Cancer 2015, 14:147 – View the full open-access article online

Targeting human cancer by a glycosaminoglycan binding malaria protein

Ali Salanti, Thomas M. Clausen, Mette Ø. Agerbæk, Nader Al Nakouzi, Madeleine Dahlbäck, Htoo Z. Oo, Sherry Lee, Tobias Gustavsson, Jamie R. Rich, Bradley J. Hedberg, Yang Mao, Line Barington, Marina A. Pereira, Janine LoBello, Makoto Endo, Ladan Fazli, Jo Soden, Chris K. Wang, Adam F. Sander, Robert Dagil, Susan Thrane, Peter J. Holst, Le Meng, Francesco Favero, Glen J. Weiss, Morten A. Nielsen, Jim Freeth, Torsten O. Nielsen, Joseph Zaia, Nhan L. Tran, Jeff Trent, John S. Babcook, Thor G. Theander, Poul H. Sorensen, Mads Daugaard


Cancer Cell 2015, 28(4):500-14 – View the abstract and full article options online

Severe malaria is associated with parasite binding to endothelial protein C receptor

Louise Turner, Thomas Lavstsen, Sanne S. Berger, Christian W. Wang, Jens E. V. Petersen, Marion Avril, Andrew J. Brazier, Jim Freeth, Jakob S. Jespersen, Morten A. Nielsen, Pamela Magistrado, John Lusingu, Joseph D. Smith, Matthew K. Higgins & Thor G. Theander


Nature 2013, 498:502 – View the full study online

The University of Sheffield
Aveo Oncology - The Human Response
Theraclone Sciences
Bluebird Bio
The Center for Infectious Disease Research
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The University of Copenhagen
Lund University
NIH - National Institutes of Health
The University of Pennsylvania
Scripps Florida - The Scripps Research Institute
Peptinnovate Ltd - Unlocking Nature's Potential
We’ve developed a terrific working relationship with the team at Retrogenix and intend to utilize their microarray technology as a standard screen for future targets. Jim and Jo have become trusted collaborators and we appreciate their flexibility and willingness to work with us through some challenging issues. The quality and timeliness of the data and reports are first rate. We’ve come to rely on their results as a dependable means to confirm results from traditional crossreactivity studies and to identify additional potential unexpected interactions.
Amy Bourdeau, ‎Senior Preclinical Development Coordinator, Bluebird bio