Below is a selection of our recent papers. If you would like to discuss how the cell microarray technology could be applied in your research please get in touch.

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.

Goydel RS, Weber J, Peng H, Qi J, Soden J, Freeth J, Park H & Rader C.

Journal of Biological Chemistry 2020

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New advances in cell microarray technology to expand applications in target deconvolution and off-target screening.

Freeth J & Soden J

SLAS Discovery 2020

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Anti-PD1 ‘SHR-1210ʹ aberrantly targets proangiogenic receptors and this polyspecificity can be ablated by paratope refinement.

Finlay WJJ, Coleman JE, Edwards JS & Johnson KS

mAbs 2018 View full text

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Siglec-6 on chronic lymphocytic leukemia cells is a target for post-allogeneic hematopoietic stem cell transplantation antibodies

Chang J, Peng H, Shaffer BC, Baskar S, Wecken IC, Cyr MG, Martinez GJ, Soden J, Freeth J, Wiestner A & Rader C.


Cancer Immunology Research 2018. Epub ahead of print

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Emerging approaches for the identification of protein targets of small molecules – A practitioners’ perspective

Comess KM, McLoughlin SM, Oyer JA, Richardson PL, Stöckmann H, Vasudevan A  & Warder SE.

Journal of Medicinal Chemistry, 2018 DOI: 10.1021/acs.jmedchem.7b01921


GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ & Rangwala SM.


Nature Medicine 2017 (doi:10.1038/nm.4392). View the abstract and full article options online.

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Novel drug targets from phenotypic screening

Freeth J, Kingsley E & Soden J.

Drug Discovery World. Fall 2017 – View article here

Mining naïve rabbit antibody repertoires by phage display for monoclonal antibodies of therapeutic utility

Peng H, Nerreter T, Chang J, Qi J, Li X, Karunadharma P, Martinez G, Fallahi M, Soden J, Freeth J, Beerli RR, Grawunder U, Hudecek M & Rader C.


Journal of Molecular Biology 2017, 429(19):2954-2973. View the abstract and full article options online.

Identification of human junctional adhesion molecule-1 as a functional receptor for the Hom-1 calicivirus on humans cells

Stanislav V. Sosnovtsev, Carlos Sandoval-Jaime, Gabriel I. Parra, Christine M. Tin, Ronald W. Jones, Jo Soden, Donna Barnes, Jim Freeth, Alvin W. Smith, Kim Y. Green


mBio 2017, 8:1 – View the full, open access article

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W. Wilkinson


Oncotarget 2016, 7:68278-68291 (doi: 10.18632) – View the full open-access article online.

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth and Ralph Minter


Molecular Cancer 2015, 14:147 – View the full open-access article online

Targeting human cancer by a glycosaminoglycan binding malaria protein

Ali Salanti, Thomas M. Clausen, Mette Ø. Agerbæk, Nader Al Nakouzi, Madeleine Dahlbäck, Htoo Z. Oo, Sherry Lee, Tobias Gustavsson, Jamie R. Rich, Bradley J. Hedberg, Yang Mao, Line Barington, Marina A. Pereira, Janine LoBello, Makoto Endo, Ladan Fazli, Jo Soden, Chris K. Wang, Adam F. Sander, Robert Dagil, Susan Thrane, Peter J. Holst, Le Meng, Francesco Favero, Glen J. Weiss, Morten A. Nielsen, Jim Freeth, Torsten O. Nielsen, Joseph Zaia, Nhan L. Tran, Jeff Trent, John S. Babcook, Thor G. Theander, Poul H. Sorensen, Mads Daugaard


Cancer Cell 2015, 28(4):500-14 – View the abstract and full article options online

Severe malaria is associated with parasite binding to endothelial protein C receptor

Louise Turner, Thomas Lavstsen, Sanne S. Berger, Christian W. Wang, Jens E. V. Petersen, Marion Avril, Andrew J. Brazier, Jim Freeth, Jakob S. Jespersen, Morten A. Nielsen, Pamela Magistrado, John Lusingu, Joseph D. Smith, Matthew K. Higgins & Thor G. Theander


Nature 2013, 498:502 – View the full study online

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We are very happy with our collaboration with Retrogenix, and how their platform has delivered.
Dr. Björn Frendéus, Vice President of Pre-clinical Research at BioInvent International A/B