Below is a selection of our recent papers. If you would like to discuss how the cell microarray technology could be applied in your research please get in touch.

KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1

Bhatt RS, Berjis A, Konge JC, Mahoney KM, Klee AN, Freeman SS, Chen CH, Jegede OA, Catalano PJ, Pignon JC, Sticco-Ivins M, Zhu B, Hua P, Soden J, Zhu J, McDermott DF, Arulanandam AR, Signoretti S and Freeman GJ.

Cancer Immunology Research, Nov 2020
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Platelet-derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP

Steel RJW, Vigdorovich V, Dambrauskas N, Wilder BK, Arredondo SA, Goswami D, Kumar S, Carbonetti S, Swearingen KE, Nguyen T, Betz W, Camargo N, Fisher BS, Soden J, Thomas H, Freeth J, Moritz RL, Sather DN, Kappe SHI.

bioRxiv – preprint May 2020
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Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.

Goydel RS, Weber J, Peng H, Qi J, Soden J, Freeth J, Park H & Rader C.

Journal of Biological Chemistry 2020
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New advances in cell microarray technology to expand applications in target deconvolution and off-target screening.

Freeth J & Soden J

SLAS Discovery 2020
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GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TL, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, Fernandez De Larrea C, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel H, Riviere I, Liu C, Sather B, & Brentjens RJ.

Science Translational Medicine 2019
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Anti-PD1 ‘SHR-1210ʹ aberrantly targets proangiogenic receptors and this polyspecificity can be ablated by paratope refinement.

Finlay WJJ, Coleman JE, Edwards JS & Johnson KS

mAbs 2018
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Siglec-6 on chronic lymphocytic leukemia cells is a target for post-allogeneic hematopoietic stem cell transplantation antibodies

Chang J, Peng H, Shaffer BC, Baskar S, Wecken IC, Cyr MG, Martinez GJ, Soden J, Freeth J, Wiestner A & Rader C.

Cancer Immunology Research 2018.
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Emerging approaches for the identification of protein targets of small molecules – A practitioners’ perspective

Comess KM, McLoughlin SM, Oyer JA, Richardson PL, Stöckmann H, Vasudevan A  & Warder SE.

Journal of Medicinal Chemistry, 2018
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ & Rangwala SM.

Nature Medicine 2017.
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Novel drug targets from phenotypic screening

Freeth J, Kingsley E & Soden J.

Drug Discovery World. Fall 2017
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Mining naïve rabbit antibody repertoires by phage display for monoclonal antibodies of therapeutic utility

Peng H, Nerreter T, Chang J, Qi J, Li X, Karunadharma P, Martinez G, Fallahi M, Soden J, Freeth J, Beerli RR, Grawunder U, Hudecek M & Rader C.

Journal of Molecular Biology 2017, 429(19):2954-2973.
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Identification of human junctional adhesion molecule-1 as a functional receptor for the Hom-1 calicivirus on humans cells

Stanislav V. Sosnovtsev, Carlos Sandoval-Jaime, Gabriel I. Parra, Christine M. Tin, Ronald W. Jones, Jo Soden, Donna Barnes, Jim Freeth, Alvin W. Smith, Kim Y. Green

mBio 2017, 8:1
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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W. Wilkinson

Oncotarget 2016, 7:68278-68291 (doi: 10.18632)
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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth and Ralph Minter

Molecular Cancer 2015, 14:147
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Targeting human cancer by a glycosaminoglycan binding malaria protein

Ali Salanti, Thomas M. Clausen, Mette Ø. Agerbæk, Nader Al Nakouzi, Madeleine Dahlbäck, Htoo Z. Oo, Sherry Lee, Tobias Gustavsson, Jamie R. Rich, Bradley J. Hedberg, Yang Mao, Line Barington, Marina A. Pereira, Janine LoBello, Makoto Endo, Ladan Fazli, Jo Soden, Chris K. Wang, Adam F. Sander, Robert Dagil, Susan Thrane, Peter J. Holst, Le Meng, Francesco Favero, Glen J. Weiss, Morten A. Nielsen, Jim Freeth, Torsten O. Nielsen, Joseph Zaia, Nhan L. Tran, Jeff Trent, John S. Babcook, Thor G. Theander, Poul H. Sorensen, Mads Daugaard

Cancer Cell 2015, 28(4):500-14
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Severe malaria is associated with parasite binding to endothelial protein C receptor

Louise Turner, Thomas Lavstsen, Sanne S. Berger, Christian W. Wang, Jens E. V. Petersen, Marion Avril, Andrew J. Brazier, Jim Freeth, Jakob S. Jespersen, Morten A. Nielsen, Pamela Magistrado, John Lusingu, Joseph D. Smith, Matthew K. Higgins & Thor G. Theander

Nature 2013, 498:502
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Retrogenix have been an excellent partner for us, and done high-quality studies. They have a collaborative approach and the flexibility to design studies to ensure the best possible outcomes.
Dr. David King, SVP Research, aTyr Pharma
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