A more comprehensive screen
Human cell microarray technology has long been the leading tool for discovering primary receptors and assessing potential off-target binding against expressed human proteins. Over a decade of continual development has ensured that the Retrogenix library is of the highest quality. Initially representing only plasma membrane monomers, the Retrogenix library now, uniquely, includes cell surface heterodimers as well as secreted proteins that have been identified as key off-targets for screening through our close collaborations with toxicology teams at leading pharmaceutical companies. Our rigorous bioinformatics approach ensures that miscategorised proteins are always excluded from our library, safeguarding the specificity of our results and providing clients with the confidence that real targets will discovered and won’t be masked by a raft of false positives.
Building the best
After > 10 years of expansion and refinement, the Retrogenix cell microarray libraries currently have >6,200 proteins for screening. This is the largest set of plasma membrane and secreted proteins expressed in human cells. As data from our specificity screens are frequently used to support IND / BLA submissions it is crucial that we always ensure our technology retains its high success rates as our capabilities continue to grow. The high degree of confidence that clients have when assessing the specificity of a novel biotherapeutic or cell therapy using Retrogenix has allowed many of them to move away from tissue cross reactivity studies altogether.